Fig. 4: Ancestry, genetic diversity and rare-variant genetic relatedness across the TOPMed studies.

Each study label is shaded based on their population group. From the outside moving in each track represents: the unrelated sample size of each study used in these calculations, average admixture values, average number of heterozygous sites in each individual’s genome, average number of singleton variants in each individual’s genome and the average within-study rare-variant (RV) sharing comparisons. The links depict the 75th percentile of between-study rare-variant sharing comparisons. All between-study rare-variant sharing comparisons can be found in Supplementary Fig. 29. The sample size, average heterozygosity, number of singletons, within-cohort rare-variant sharing and admixture values by TOPMed study and population group can be found in Supplementary Table 13. Study name abbreviations are defined in Extended Data Tables 1, 2 and Supplementary Table 20.