Extended Data Fig. 5: Non-coding driver candidates.

a, MTG2 promoter locus (left) and associated gene-expression changes in carcinoma tumours (right). Expression of MTG2 in mutated (n = 3) versus the carcinoma meta-cohort wild-type cases (n = 896). Two-sided Wilcoxon rank-sum test. Bars represent means. b, Genomic locus of NFKBIZ 3′ UTR (left) and associated gene-expression changes in Lymph–BNHL (right). Expression of NFKBIZ in mutated (n = 6) versus wild-type cases (n = 98). Test and bars as in b. c, Genomic locus of the RMRP transcript and promoter region (left). RMRP is an RNA component of the endoribonuclease RNase MRP, the function of which depends on its RNA secondary and tertiary structure. The RNA secondary structure, tertiary structure interactions, protein and substrate interactions, and mutations with their predicted structural effect (right) of RMRP; lymphoma and melanoma mutations are excluded. d, MIR142 locus and mutations in patients with lymphoma with the AID signature annotation. e, Manhattan-style plot showing significance of mutation recurrence enrichment for genomic bins (top) and ultraconserved elements (bottom) across cohorts (Methods; Supplementary Table 9).