Extended Data Fig. 8: Mutation spectrum of sSNVs in human neurons.
From: Single-cell transcriptomic and genomic changes in the ageing human brain
(a) Total mutation accumulation per neuron correlates significantly with age at a rate of 15.1 SNVs gained/year (p = 2.2×10−16, Pearson’s correlation). (b) Mutation spectrum of sSNVs called in human neuron scWGS data. Each bar represents a specific mutation in a different trinucleotide context. (c) Cosine similarity of the two signatures, A1 and A2, derived de novo from the total mutation spectrum to each single-base substitution signature in the COSMIC database. Signature A1 is most similar to SBS5. Signature A2 is most similar to SBS30.