Extended Data Fig. 9: Evolutionary comparison of lung cell types across human, lemur, mouse, and macaque.
From: A molecular cell atlas of mouse lemur, an emerging model primate
a. Bar plots comparing differences (Δrc) between human-to-macaque (rcHMa), human-to-lemur (rcHL) and human-to-mouse (rcHM) transcriptomic correlation coefficients (top to bottom: ΔrcMa-L = rcHMa-rcHL, ΔrcL-M = rcHL-rcHM, ΔrcMa-M = rcHMa-rcHM)) for each of the 18 orthologous lung cell types indicated. p < 0.05, * (right-tailed t-test), ◊(left-tailed). Bottom panel, correlation coefficient between each species. b. Dot plot showing mean expression of genes highly-conserved between human, lemur, and mouse (as in Fig. 5i and Supplementary Fig. 4a) in the 18 orthologous lung cell types across human, macaque, lemur, and mouse. Genes without an orthologue in macaque were excluded. Note that macaque cell types generally showed similar expression patterns to cognate cell types in the other three species, but with exceptions (notable examples indicated by arrowheads). Format as in Fig. 5i.