Extended Data Fig. 8: Evolutionary comparisons of hematopoiesis.
From: A molecular cell atlas of mouse lemur, an emerging model primate
a-d. UMAP of bone marrow and spleen immune cells integrated across species as in Fig. 5d, with cells colored by cell type (a) and pseudotime along the hematopoietic trajectories (b, neutrophil; c, monocyte/macrophage; d, erythroid). e,f. Correlation coefficients of human progenitor and mature immune cell transcriptomic profiles to those of lemur (rcHL) and mouse (rcHM) as shown in Fig. 5e but for monocyte/macrophage (e) and erythroid (f) trajectories. Note that rcHL is almost always greater than rcHM throughout the trajectories with the exception of the end of the monocyte/macrophage trajectory, likely confounded by different fractions of macrophages in each dataset. g-j. Dot plot showing mean expression along neutrophil (g, j), monocyte/macrophage (h), and erythroid (i) trajectories, for known markers genes (g-i) and evolutionary conserved/divergent genes (j: top, all species conserved; bottom, primate-conserved and mouse divergent). Rows are orthologous genes, indicated by their human gene symbols. Columns are cell types, displayed as trios of dots showing expression in the corresponding human, lemur, and mouse cell type.