Fig. 4: Relationships of molecular cell types across the lemur atlas.
From: A molecular cell atlas of mouse lemur, an emerging model primate
a, UMAP of molecular cell types (dots) in the atlas based on their mean transcriptomic profiles (L1–L4, 10x). Dot fill colour, tissue compartment; black or grey outline, progenitor or proliferating cell types, respectively. Dashed contours, biologically related cell types. Arrow and arrowhead, unexpected molecular convergence highlighted in b–d; boxed regions are shown in e and f. b–d, UMAPs as in a showing relative expression level heatmaps of the indicated DEGs for the following comparisons: immune progenitor and proliferating cells and germ cells versus cell types in other compartments (b; additional genes in Extended Data Fig. 5j); immune progenitor and proliferating cells and germ cells versus proliferating cells in other compartments (c; additional genes in Extended Data Fig. 5j); and Schwann and stromal cells versus non-Schwann cell types in the neural compartment (d; additional DEGs include SOCS3, COL1A2, COL5A2, ID3, ID1, CDC42EP5, MMP2, TGFBR2, CCN1 and TBX3). e,f, Close-up of the boxed regions in a showing segregation of two types of lymphatic cell independent of tissue of origin (e), versus tissue-specific segregation of skin and tongue epithelial cell types despite their relatively similar functions in both tissues (for example, basal cells) (f).