Extended Data Fig. 7: Control of immune cell development, activation, and senescence.

Atlas-informed control of multi-organ tumor progression and the local and systemic inflammatory programs in L2, diagnosed with endometrial cancer (Step 1), metastatic spread to lung (2), secondary bacterial infection in both organs, plus suppurative cystitis (3) and suspected inflammation in perigonadal fat (4). Involved cell types in bone marrow (bottom left), circulating in blood vessels (middle), in the inflamed tissues (top), and in lymph nodes (bottom right) are shown along with their marker genes, and the signals (ligand–receptor pairs in tan boxes, colored as in Fig. 2a) proposed to control the local and systemic inflammatory steps (5-9) are indicated. Detailed description in Supplementary Note 5. Schematic created in BioRender. Ezran, C. (2025) https://BioRender.com/r8i9ddj.