Extended Data Fig. 3: Additional examples of expression homologue triads.

Dot plots as in Fig. 1m with additional examples of expression homologue triads (named, unnamed, missed orthologue, and non-orthologue types) across human, lemur, and mouse lung and skeletal muscle cell types indicated. Corresponding triad diagrams are shown on the right. Note, three RAMP expression homologue triads are detected: two non-orthologues (i.e., hu RAMP2 - le RAMP1* - ms Ramp2, hu RAMP3* - le RAMP2 - ms Ramp2) and one named orthologue (hu RAMP2 - le RAMP2 - ms Ramp2). Asterisk indicates the outlier non-orthologous gene. The shared expression patterns of lemur RAMP1 and human RAMP3 with RAMP2 suggests that lemur RAMP1 and human RAMP3 have evolved to engage in similar physiological functions as the species-conserved RAMP2 or to modulate RAMP2-mediated ligand signaling in lung endothelial cells. Similar non-orthologous expression homologues were identified for TEKT1/3, ADAMTS8/S15, and AEBP1/CPXM1.