Fig. 4: Lemur expression patterns of PS genes.
From: Mouse lemur cell atlas informs primate genes, physiology and disease
a, Scheme for identifying and characterizing PS genes. The pie chart shows the fraction of the approximately 20,000 human protein-coding genes with identified orthologues (in NCBI, Ensembl and/or Mouse Genome Informatics) in lemur and/or mouse. The 539 (3%) that share an orthologue only with lemur (PS genes) correspond to 481 lemur genes b, Number of PS genes enriched (or depleted) in a specific tissue compartment. Cross-compartment, enriched or depleted in >1 compartment. c,d, Sina plots showing the expression of example PS genes that are compartment enriched or depleted (c) or organ-enriched (d) (10x data), with cell types (dots) grouped by compartment (c) or by organ (d). e, Dot plot of the mean expression of PS genes enriched or depleted in the germ compartment. Values are averaged across all cells in the indicated non-germ compartments and germ cell types (10x data). f, Dot plot of the mean expression of selected PS genes in 63 orthologous cell types in human and lemur lung (L), skeletal muscle (M), liver, testes, and bone marrow and spleen (B/S)1. Rows, orthologous genes (indicated with human gene symbols). Columns, cell types displayed as paired dots showing expression in humans and lemurs. Symbols in brackets indicate the description of genes identified by NCBI as loci: [TRGC10], LOC105878255; [AMY2BL], LOC105863954; [MT1EL], LOC105866478; [CARD18L], LOC105862464, [H2BC12], LOC105858749; [AK1], LOC105869668; [HSFX4], LOC109730266; [SPANXN4], LOC105864720; [EXT], LOC105877793; [MT2A], LOC105866476; [MT2AL], LOC105866477; [MT1XL], LOC105866553; [H2H2BE], LOC105865505; [RPL36AL], LOC105873222. D/S, diplotene/secondary; EP, erythroid progenitor; Hep, hepatocyte; MG, mammary gland; MGP, megakaryocyte progenitor; MK, megakaryocyte; MuSC, skeletal muscle stem cell; VSM, vascular smooth muscle. See also Supplementary Figs. 5 and 6.