Fig. 5: Enrichment of psychiatric SNPs in first-trimester central nervous system cell types.
From: Chromatin accessibility during human first-trimester neurodevelopment
a, −log10[P values] for neuropsychiatric phenotypes derived from stratified linkage disequilibrium score regression analysis (one-sided). Asterisks indicate significant (FDR or Bonferroni) differences. Only cell types reaching significance in one of the phenotypes are plotted. ADHD, attention-deficit hyperactivity disorder. CGE, caudal ganglionic eminence; LGE, lateral ganglionic eminence; MGE, medial ganglionic eminence. b, MAGMA −log10[P values] for gene-associated cCREs with the Benjamini–Hochberg α set at 1.2 × 104. c, Enriched TF-binding motifs in the MDD-associated SNPs passing Bonferroni correction (HOMER; one-sided; no multiple test correction). MEIS2, OTX2 and GATA2 are TFs strongly associated with midbrain inhibitory neurons. d, The contribution scores of region chr 6: 28,885,244–28,885,645, which contains rs114155007, one of the SNPs associated with MDD.