Fig. 3: Associations of cluster-specific components of the partitioned PS with five T2D-related vascular outcomes in up to 279,552 individuals from multiple ancestry groups.
From: Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
Summaries of the associations of each cluster-specific component of the partitioned PS with CAD, ischaemic stroke (IS), peripheral artery disease (PAD), ESDN and proliferative diabetic retinopathy (PDR). The height of each bar corresponds to the log-odds ratio (beta) per standard deviation of the PS, and the grey bar shows the 95% confidence interval. Analyses of T2D-related macrovascular complications (CAD, PAD and IS) were undertaken in all individuals, with adjustment for T2D status. Analyses of microvascular complications were undertaken in individuals with T2D only. *P < 0.05, nominal association; **P < 0.0063, Bonferroni correction for eight clusters. Exact P values are provided in Supplementary Table 21.