Fig. 1: Exome-wide association analysis.
From: Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls
a, Single-variant associations were calculated using the two-sided EMMAX test. Red line, P = 4.3 × 10−7. b, Gene-level P values, corrected for four analyses performed using the two-sided minimum P-value test. The most-significant genes are labelled. Red line, P = 6.5 × 10−7. c, SLC30A8 gene-level P values (left y axis, black line), calculated using a two-sided burden test after removing variants (in order of increasing single-variant P value) from the 1/5 1% mask (the strongest signal for SLC30A8). Dashed line, P = 0.05. Right y axis (blue line), estimated effect size (log10(odds ratio)). Blue shading, 95% confidence interval. Dotted line, effect size = 0. Single-variant n = 45,231 individuals. Gene-level n = 43,074 unrelated individuals.