Fig. 5: Upregulation of spontaneous GABAA-R signaling in SNc dopamine cells from MCI-Park mice.
From: Morphological and functional decline of the SNc in a model of progressive parkinsonism
A Representative recordings of spontaneous GABAA IPSCs from control (black) and MCI-Park (red) cells in the presence of nbqx for each age group. B Summary data of spontaneous IPSC frequencies in control (gray) or MCI-Park (red) animals at 30–34 days (n = C:18/3, M:15/7; p = 0.0008) 35–39 days (n = C:24/6, M:15/5; p = 0.0102). and 40–44 days (n = C:17/6, M:12/5; p = 0.0003). C Representative recordings of evoked GABAA IPSCs in control and MCI-Park cells across age groups. D Summary data of the amplitude (inverted) of evoked GABAA IPSCs in control (gray) and MCI-Park (red) cells at 30–34 days (n = C:11/4, M:6/3; NS, p = 0.5464), 35–39 days (n = C:10/4, M:7/4; ns, p = 0.3118), and 40–44 days (n = C:21/10, M:9/4; ns, p = 0.0648). All groups compared using Sidak’s test following two-way ANOVA; data in (B) are mean ± SD, data in (D) are mean + SD. n reported as (cells/animals) for control (C) or MCI-Park (M) groups.