Fig. 2: Differentially expressed genes between younger versus older patients.
From: Molecular differences between younger versus older ER-positive and HER2-negative breast cancers
Volcano plots indicate the log2 fold change (FC) and FDR of differentially expression analysis in three cohorts, including a TCGA cohort; b microarray cohort-A; c microarray cohort-B. P-values were generated by Student’s t-test and corrected by Benjamini–Hochberg FDR. Red dots indicated genes meet criteria of fold change ≥ 1.50 or ≤ 0.67 and FDR < 0.05 (significant), and other genes were marked as gray (none, not significant). Top enriched genes with fold change ≥ 1.50 or ≤ 0.67 and FDR < 1e−05 were labeled with official gene symbols. d, e Venn diagram shows the number of upregulated (d) and downregulated (e) genes identified in the TCGA that also showed up- or downregulation in the other two data sets.