Fig. 3: High density of macrophages and high PD-L1 expression were found in SFTs. | Nature Communications

Fig. 3: High density of macrophages and high PD-L1 expression were found in SFTs.

From: Comprehensive analysis reveals potential therapeutic targets and an integrated risk stratification model for solitary fibrous tumors

Fig. 3

a Boxplot indicating that the tumor infiltrating immune cells in SFTs (SYSUCC cohort, n = 131) are predominantly macrophages. Box center lines, bounds of the box, and whiskers indicate medians, first and third quartiles, and minimum and maximum values within 1.5×IQR (interquartile range) of the box limits, respectively. p values were calculated using Kruskal–Wallis test. b–d High density of CD68+ macrophages, CD163+ macrophages, and HLA-DPB1+ cells infiltrated in SFTs tissues was associated with shorter PFS of the patients. p values were calculated using two-sided log-rank test. e PD-L1 was highly expressed in both tumor cells and CD68+/HLA-DPB1+/CD163+ macrophages in SFTs (scale bars: 100 μm/5 μm). Multiplex immunofluorescence was performed on three cases of SFT tissues and the representative images are presented here. HR Hazard Ratio, PFS Progression Free Survival. Source data are provided as a Source Data file.

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