Fig. 3: Factor-associated loci perturb different nodes of the same pathways. | Nature Communications

Fig. 3: Factor-associated loci perturb different nodes of the same pathways.

From: Cross-disorder genetic analysis of immune diseases reveals distinct gene associations that converge on common pathways

Fig. 3

a KEGG pathway enrichment analysis of factor-associated genes. The heatmap shows KEGG pathways that were significantly enriched (p adjusted < 0.05) in factor-associated genes. The radius of the circle is proportional to the −log10(p-adjusted). P values were calculated with the hypergeometric test and corrected for multiple testing with the gprofiler-g:SCS. The tile plot shows enriched genes in each of the pathways. Blue, green and red represent the genes that contributed to the enrichment of Fgut, Faid and Falrg respectively. b Schematic representation of JAK-STAT signalling pathway. Blue, green and red represent components of the pathway that contribute to the enrichment from Fgut, Faid and Falrg respectively. Adapted from ‘Cytokine Signaling through the JAK-STAT Pathway’, by BioRender.com (2023). Retrieved from https://app.biorender.com/biorender-templates.

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