Table 3 Conditional and joint analyses identified independently associated risk SNPs for lung adenocarcinoma at two existing loci in East Asians

From: Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

   

Gene

GWAS analysisa

Conditional analysisb

Joint analysisc

Chr

BP

SNP

Eff/Ref

EAF

OR (95% CI)

P

OR (95% CI)

P

OR (95% CI)

P

5

1280477

rs13167280

TERT

A/G

0.22

1.47(1.37,1.57)

6.99 × 10−30

1.33(1.24,1.42)

8.36 × 10−17

1.29(1.20,1.38)

4.07 × 10−13

5

1286516

rs2736100

A/G

0.56

0.75(0.72,0.77)

7.92 × 10−58

  

0.80(0.77,0.83)

9.83 × 10−32

5

1290319

rs62332591

G/T

0.52

0.79(0.75,0.83)

3.53 × 10−23

0.87(0.83,0.91)

2.95 × 10−9

0.87(0.83,0.92)

3.21 × 10−8

6

41483390

rs9367106

FOXP4

C/G

0.32

1.20(1.15,1.26)

1.06 × 10−14

  

1.19(1.14,1.25)

2.39 × 10−13

6

41483960

rs12664490

T/C

0.16

0.80(0.75,0.85)

5.52 × 10−12

0.81(0.76,0.86)

1.34 × 10−10

0.81(0.76,0.86)

1.24 × 10−10

  1. All p values are nominal and two-sided.
  2. aData from single-variant analysis in GWAS.
  3. bConditional analysis using GCTA, conditioning on the lead variant in each locus.
  4. cJoint analysis using GCTA including the lead variant and the significant variants in conditional analysis.
Back to article page