Fig. 2: Colocalization of lung adenocarcinoma GWAS signal from the new locus on Chr11 with FADS1 eQTL signal. | Nature Communications

Fig. 2: Colocalization of lung adenocarcinoma GWAS signal from the new locus on Chr11 with FADS1 eQTL signal.

From: Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Fig. 2

Colocalization analysis was performed using HyPrColoc with summary statistics from Taiwanese lung eQTL data (for FADS1 gene, A) and those of EA GWAS discovery set (B). LD R2 (1000 Genomes, EA) of each SNP with the GWAS lead SNP, rs174559 (red circle), is color-coded as shown in the top band. Colocalization posterior probability (PP) is shown next to the candidate SNP, rs174559. Note that the p value of rs174559 in GWAS was based on the discovery data and did not include the Japanese replication data. All eQTL p values were two-sided and not adjusted for multiple testing.

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