Fig. 4: A polygenic risk score (PRS) is more strongly associated with risk of lung adenocarcinoma in never-smokers than in individuals with a history of smoking (P = 0.0058). | Nature Communications

Fig. 4: A polygenic risk score (PRS) is more strongly associated with risk of lung adenocarcinoma in never-smokers than in individuals with a history of smoking (P = 0.0058).

From: Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Fig. 4

The PRS was defined based on 25 independent variants that achieved genome-wide significance in EA with weights derived from the meta-analysis of the current study (Supplementary Table 4). The odds ratios (ORs) and the standard errors of the 12 novel variants were based on 21,658 cases and 150,676 controls. The ORs and the standard errors of the other 13 variants were based on 11,753 cases and 30,562 controls. The figure shows the ORs and their 95% confidence intervals comparing each quintile group to the middle quintile for individuals with a history of smoking (blue) and never-smokers (red).

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