Fig. 2: Prioritizing drug targets based on lipid effect and liver enzyme associations.
From: Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease
For any variant significantly (P < 5 × 10−8) associated with a lipid trait (HDL-C, LDL-C, TG, TC), the maximum effect size in terms of the allele associated with good lipid health (e.g., lowered LDL-C, increased HDL-C, lowered TG, and lowered TC) is compared to the minimum p value for association with liver trait (ALT, ALP, AST, GGT). Vertical whiskers represent 95% confidence intervals of the effect size. Nominal P value of 0.05 (vertical dashed line) is indicated to highlight variants in the bottom right quadrant which lack significance for association with liver traits. These variants are better drug target candidates given estimated favorable lipid-effects on health and absence of association with potentially unfavorable liver traits.