Fig. 1: Modeling diverse subtypes of fusion-driven sarcoma.
From: Somatic gene delivery faithfully recapitulates a molecular spectrum of high-risk sarcomas
a Scheme of versatile vector combination for in situ sarcoma induction. Reporter genes were not utilized here. Created in BioRender. Banito, A. (2025) https://BioRender.com/kpnm994. b Matrix of vector combinations chosen based on human sarcoma profiling studies. c Kaplan–Meier curves of murine PAX3::FOXO1-driven tumor induction and representative histographs compared to human aRMS (d). e Kaplan–Meier curves of murine SS18::SSX1/2 tumor induction and representative histographs compared to human SS (f). g Kaplan–Meier curves of murine ASPSCR1::TFE3-driven tumor induction and representative histographs compared to human ASPS (h). i Kaplan–Meier curves of murine ETV6::NTRK3-driven tumor induction and representative histographs compared to human IFS and the emerging WHO entity of NTRK-rearranged spindle cell neoplasm (NRSCN) (j). Murine tumors exhibited two main histological types, named ETV6::NTRK3-Monomorphic and ETV6::NTRK3-Pleomorphic. If not specified otherwise, histographs were stained by H&E. All Kaplan–Meier curves correspond to n ≥ 6 mice per group electroporated bilaterally. P values for comparing Kaplan–Meier curves were determined by two-sided log-rank tests and corrected for multiple testing with the Benjamini-Hochberg method. Scale bars = 50 µm. Source data are provided as a Source data file.