Fig. 1: Schematic of the study and mosaic chromosomal alterations in TOPMed. | Nature Communications

Fig. 1: Schematic of the study and mosaic chromosomal alterations in TOPMed.

From: Determinants of mosaic chromosomal alteration fitness

Fig. 1

A Excluding mosaic chromosomal alterations (mCAs) of chromosome X, 3068 individuals had 3,828 mCAs in TOPMed. 6,930 individuals had 1 mCA, and 763 had > 1 mCA. Created with BioRender.com released under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International license. B Stacked bar plot showing counts of mCAs by chromosome, separated by copy change type: copy neutral loss of heterozygosity (CN-LOH) in yellow, gain in red, and loss in blue. mCAs of chromosome X were excluded. C Dot plot of clonal fractions for each patient with specific mCA (chromosome and copy change). Red and + represents gain of chromosome, blue and - represents loss of chromosome, and yellow and = represents CN-LOH.

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