Fig. 1
From: SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix
Severe osteopenia in Sirt7 KO mice. a–i μCT analysis of the distal femur in female Sirt7 KO mice and WT mice aged 14–15 weeks. Representative μCT images (a), Ct.Ar (b), Ct.Ar/Tt.Ar (c), Ct.Th (d), Ecc (e), trabecular BV/TV (f), Tb.Th (g), Tb.N (h), and Tb.Pf (i). j Mendelian frequency of the Sirt7 genotype and sex ratio in breeding of heterozygous Sirt7 mice. Pearson’s Chi-square test indicated that the differences between WT and Sirt7 KO mice were not statistically significant. k Two-month survival rates of the mice. l, m Comparison of body weight (l) and serum concentrations of Ca and P (m) between 11-week-old female Sirt7 KO mice and WT mice. Data are shown as the mean ± SEM. Statistical significance was determined by Student’s t-test. *p < 0.05 vs. WT mice (b–i, l, m). Scale bar, 1 mm