Fig. 4
From: SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix
Osteoblast-specific Sirt7 KO mice exhibit reduction of bone mass due to decreased bone formation. a–f μCT analysis of the distal femur in 15-week-old female Sirt7 osbCKO mice and control mice. Trabecular BV/TV (a), Tb.Th (b), Tb.Pf (c), Ct.Ar (d), Ct.Ar/Tt.Ar (e), and Ct.Th (f). g–l Static and dynamic bone histomorphometric analyses of the lumbar spine (L4) in 15-week-old female Sirt7 osbCKO mice and control mice. Representative von Kossa-stained images and BV/TV (g), as well as MAR (h), BFR/TV (i), N.Ob/T.Ar (j), Oc.S/BS (k), and N.Oc/B.Pm (l). Data are shown as the mean ± SEM. Statistical significance was determined by Student’s t-test. *p < 0.05 vs. control mice. Scale bar, 1 mm