Table 4 Univariable analysis for genetic risk factor of proportion of beta-PPA to Disc (Cases).

From: Risk factors associated with beta-peripapillary atrophy in individuals of African ancestry with primary open-angle glaucoma

 

N

Proportion of beta-PPA changes (95% CI)

P value

q1 (per 0.1 units

954

−0.01 (−0.03, 0.02)

0.57

Genetic risk score (per 1 unit increase

954

0.06 (−0.10, 0.21

0.47

Polygenic risk score (per 1 unit increase)

954

−0.01 (−0.08, 0.06)

0.77

 

Alleles present

N

Mean (SD)

P value

(rs1666698_ALT/DBF4P2) chr2:111570643:T:C

0

46

0.51 (0.98)

0.37

1

325

0.48 (1.00)

2

489

0.38 (0.47)

(rs11824032_ALT/ARHGEF12) chr11:120354080:G:A_G

0

462

0.41 (0.86)

0.92

1

330

0.43 (0.56)

2

68

0.46 (0.71)

(rs34957764_ALT/ROCK1P1) chr18:93327:C:T_C

0

767

0.43 (0.78)

0.03

1

93

0.32 (0.39)

  1. Univariable analysis for genetic risk factors of proportion of beta-PPA. q1 represents the degree of African ancestry. The genetic and polygenic risk scores were developed by our group to predict the likelihood of developing POAG. GRS and PRS were analysed as raw scores for consistency with prior POAAGG studies. Standardised (z-score) versions of these scores yielded similar results and are available upon request. The 3 SNPS were identified by a large GWAS study as likely causal of POAG.
Back to article page