Fig. 3: Blocking the HGF/c-Met signaling pathway inhibits PNI in pancreatic cancer. | Cell Death & Disease

Fig. 3: Blocking the HGF/c-Met signaling pathway inhibits PNI in pancreatic cancer.

From: HGF/c-Met pathway facilitates the perineural invasion of pancreatic cancer by activating the mTOR/NGF axis

Fig. 3

A, B Cancer cell-DRG coculture model for the NC and sh Met groups in PANC-1 cells and BxPC-3 cells. C, D Western blot analysis of the expression of c-Met, N-cadherin, E-cadherin, Vimentin, and NGF in the wild-type, NC, sh Met-1, and sh Met-2 groups in PANC-1 cells and BxPC-3 cells. E, F Wound healing assay of the NC and sh Met groups in PANC-1 cells and BxPC-3 cells. G, H Transwell-based assay of the NC and sh Met groups in PANC-1 cells and BxPC-3 cells. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

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