Supplementary Figure 4: Memantine and MPEP do not normalize impaired ultrasonic vocalization and open-field hyperactivity in IRSp53−/− mice, but memantine rescues novel object recognition.
From: Social deficits in IRSp53 mutant mice improved by NMDAR and mGluR5 suppression
(a-d) Animals were treated with memantine (10 mg/kg; i.p.) or MPEP (30 mg/kg; i.p.) 30 min before the indicated behavioral measurements. (a and b) Ultrasonic vocalization (SEM, n = 8 for WT saline, 8 for WT memantine, 6 for WT MPEP, 8 for KO saline, 8 for KO MPEP, and 8 for KO memantine, **P < 0.01, ns, not significant, two-sided Student's t-test). (c) Hyperactivity (SEM, n = 8 for WT saline, 10 for WT memantine, 14 for WT MPEP, 9 for KO saline, 9 for KO memantine, and 14 for KO MPEP, *P < 0.05, **P < 0.01, two-sided Student's t-test). (d) Novel object recognition (SEM, n = 7 for WT saline and memantine, 6 for KO saline and memantine, **P < 0.01, ***P < 0.001, ns, not significant, two-sided Student's t-test).