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Behind the paper: Stepping up to the antiplatelet

Nature Medicine volume 17, page 42 (2011)Cite this article

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In March 2002, a middle-aged man was admitted to the German Heart Centre in Munich to receive treatment for a blocked coronary artery. After undergoing balloon angioplasty and having a stent implanted, the man needed some sort of blood-thinning therapy, yet aspirin, the workhorse treatment for preventing arterial clots, gave him asthma attacks. His cardiologist, Nicolas von Beckerath, turned to clopidogrel, an antiplatelet drug that had been approved in the EU four years earlier under the brand name Plavix. The man tolerated the drug well, but clopidogrel did not seem to inhibit his platelet activity, even at very high doses.

“Surprisingly, we saw that this patient was absorbing the drug very well, but he wasn't metabolizing it,” says von Beckerath, now at the Viersen General Hospital in Germany.

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  1. Elie Dolgin
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Dolgin, E. Behind the paper: Stepping up to the antiplatelet. Nat Med 17, 42 (2011). https://doi.org/10.1038/nm0111-42

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