Extended Data Figure 2: Manhattan and quantile–quantile (QQ) plots of the trans-ancestry meta-analysis for BW.
From: Genome-wide associations for birth weight and correlations with adult disease
a, Manhattan (main panel) and QQ (top right) plots of genome-wide association results for BW from trans-ancestry meta-analysis of up to 153,781 individuals. The association P value (on −log10 scale) for each of up to 22,434,434 SNPs (y axis) was plotted against the genomic position (NCBI Build 37; x axis). Association signals that reached genome-wide significance (P < 5 × 10−8) are shown in green if novel and pink if previously reported. In the QQ plot, the black dots represent observed P values and the grey line represents expected P values under the null distribution. The red dots represent observed P values after excluding the previously identified signals5. b, Manhattan (main panel) and QQ (top right) plots of trans-ethnic GWAS meta-analysis for BW highlighting the reported imprinted regions described in Supplementary Table 14. Novel association signals that reached genome-wide significance (P < 5 × 10−8) and mapped to imprinted regions are shown in green. Genomic regions outside imprinted regions are shaded in grey. SNPs in the imprinted regions are shown in light blue or dark blue, depending on chromosome number (odd or even). In the QQ plot, the black dots represent observed P values and the grey lines represent expected P values and their 95% confidence intervals under the null distribution for the SNPs within the imprinted regions.