Table 2 Evidence for signal of association at previously robustly replicated loci
From: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
Collection | Gene | Chromosome | Reported SNP | WTCCC SNP | HapMap r2 | TrendP value | Genotypic P value |
|---|---|---|---|---|---|---|---|
CAD | APOE | 19q13 | * | rs4420638 | - | 1.7 × 10-01 | 1.7 × 10-01 |
CD | NOD2 | 16q12 | rs2066844 | rs17221417 | 0.23 | 9.4 × 10-12 | 4.0 × 10-11 |
CD | IL23R | 1p31 | rs11209026 | rs11805303 | 0.01 | 6.5 × 10-13 | 5.9 × 10-12 |
RA | HLA-DRB1 | 6p21 | * | rs615672 | - | 2.6 × 10-27 | 7.5 × 10-27 |
RA | PTPN22 | 1p13 | rs2476601 | rs6679677 | 0.75 | 4.9 × 10-26 | 5.6 × 10-25 |
T1D | HLA-DRB1 | 6p21 | * | rs9270986 | - | 4.0 × 10-116 | 2.3 × 10-122 |
T1D | INS | 11p15 | rs689 | † | - | - | - |
T1D | CTLA4 | 2q33 | rs3087243 | rs3087243 | 1 | 2.5 × 10-05 | 1.8 × 10-05 |
T1D | PTPN22 | 1p13 | rs2476601 | rs6679677 | 0.75 | 1.2 × 10-26 | 5.4 × 10-26 |
T1D | IL2RA | 10p15 | rs706778 | rs2104286 | 0.25 | 8.0 × 10-06 | 4.3 × 10-05 |
T1D | IFIH1 | 2q24 | rs1990760 | rs3788964 | 0.26 | 1.9 × 10-03 | 7.6 × 10-03 |
T2D | PPARG | 3p25 | rs1801282 | rs1801282 | 1 | 1.3 × 10-03 | 5.4 × 10-03 |
T2D | KCNJ11 | 11p15 | rs5219 | rs5215 | 0.9 | 1.3 × 10-03 | 5.6 × 10-03 |
T2D | TCF7L2 | 10q25 | rs7903146 | rs4506565 | 0.92 | 5.7 × 10-13 | 5.1 × 10-12 |