Figure 6: Immune cell composition and transcriptional differences in syCRCs and soCRCs. | Nature Communications

Figure 6: Immune cell composition and transcriptional differences in syCRCs and soCRCs.

From: Patients with genetically heterogeneous synchronous colorectal cancer carry rare damaging germline mutations in immune-related genes

Figure 6

(a) Neutrophil-to-lymphocyte ratio in syCRCs and in soCRCs. The number of samples is different in the two comparisons because not all types of information were available for all samples. Distributions were compared using the one-tailed Wilcoxon rank-sum test. (b) Neutrophil-to-lymphocyte ratio in MSS syCRCs and in MSS soCRCs. Distributions were compared using the one-tailed Wilcoxon rank-sum test. (c) Neutrophil-to-lymphocyte ratio in MSI and MSS syCRCs and in lesion T1 and T2 of syCRC patients. Distributions were compared using the one-tailed Wilcoxon rank-sum test. (d) Examples of immunostaining for neutrophils (neutrophil elastase) in syCRC and soCRC. Magnification 400 × ; scale bar, 30 μm. (e) KEGG gene sets that were enriched (FDR <10%) is not expressed and lowly expressed genes in syCRCs (14) as compared to soCRCs (193). Average percentage of genes in each gene set in the two cohorts of tumours is shown. For each distribution, reported are the median value (horizontal line) and 1.5 times the interquartile ranges (whiskers).

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