Figure 5: Absolute neutrophil count stratified by HLA risk allele carrier status.
From: Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles
(a) For cases in which the lowest recorded absolute neutrophil count (ANC) data were available, we ordered samples by the ANC and coloured the points by their imputed carrier status of HLA-DQB1 126Q and HLA-B 158T (black=no risk alleles, red=only a carrier of HLA-DQB1 risk alleles as tagged by 126Q, green=only a carrier of HLA-B 158T, blue=carrier of both HLA-DQB1 and HLA-B risk alleles). The background colours demonstrate the clinical definitions for agranulocytosis (red: ANC<500) and severe granulocytopenia (yellow: 500≤ANC≤1000). (b) The same data are shown as a box plot to demonstrate that HLA-B 158T carriers demonstrate a trend towards lower ANC than noncarriers of HLA-B 158T.