Table 1 Changes in parameters in OLETF and LETO rats at 8 and 25 weeks of age
8 weeks old | 25 weeks old | |
|---|---|---|
Body weight (g) | ||
LETO | 244.7±5.0 | 498.8±4.8 |
OLETF | 282.0±4.0** | 624.6±7.5** |
Total food intake (g per week) | ||
LETO | 263.0±28.6 | 250.8±2.5 |
OLETF | 206.3±11.0 | 203.3±10.00 |
Total fluid intake (g per week) | ||
LETO | 166.3±6.5 | 172.5±9.1 |
OLETF | 109.6±16.3* | 144.2±7.5 |
Blood glucose (mg dl−1) | ||
LETO | 104.0±2.9 | 138.0±4.9 |
OLETF | 109.5±2.9 | 204.0±6.3** |
Plasma insulin (μU ml−1) | ||
LETO | 6.6±0.7 | 11.4±2.2 |
OLETF | 11.7±2.1* | 88.9±0.7** |
HOMA -IR | ||
LETO | 1.67±0.1 | 3.9±0.9 |
OLETF | 3.1±0.5 | 44.8±4.6** |
Plasma total cholesterol (mg dl−1) | ||
LETO | 77.8±0.5 | 117.1±1.4 |
OLETF | 84.5±4.7 | 123.4±10.9** |
Plasma triglyceride (mg dl−1) | ||
LETO | 50.9±5.6 | 121.5±32.9 |
OLETF | 92.0±3.6** | 297.2±17.6** |
Systolic blood pressure (mm Hg) | ||
LETO | 120.6±1.7 | 135.4±1.5 |
OLETF | 134.7±2.4** | 159.0±2.5** |