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10 result(s) for 'author#Brian W. Kunkle' within BMC
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Citation: World Allergy Organization Journal 2007 1(Suppl 3):132
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Alzheimer’s disease genetic risk and cognitive reserve in relationship to long-term cognitive trajectories among cognitively normal individuals
Both Alzheimer’s disease (AD) genetic risk factors and indices of cognitive reserve (CR) influence risk of cognitive decline, but it remains unclear whether they interact. This study examined whether a CR inde...
Citation: Alzheimer's Research & Therapy 2023 15:66 -
The 5th International Conference on Molecular Neurodegeneration: Overlapping Pathologies and Common Mechanisms
Citation: Molecular Neurodegeneration 2019 14(Suppl 1):30 -
Association of MAPT haplotypes with Alzheimer’s disease risk and MAPT brain gene expression levels
MAPT encodes for tau, the predominant component of neurofibrillary tangles that are neuropathological hallmarks of Alzheimer’s disease (AD). Genetic association of MAPT variants with l...
Citation: Alzheimer's Research & Therapy 2014 6:39 -
Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer’s disease
Limited ancestral diversity has impaired our ability to detect risk variants more prevalent in ancestry groups of predominantly non-European ancestral background in genome-wide association studies (GWAS). We c...
Citation: Genome Biology 2025 26:210 -
Integrative analysis of summary data from GWAS and eQTL studies implicates genes differentially expressed in Alzheimer’s disease
Although genome-wide association studies (GWAS) have successfully located various genetic variants susceptible to Alzheimer’s Disease (AD), it is still unclear how specific variants interact with genes and tis...
Citation: BMC Genomics 2022 23(Suppl 4):414 -
Genome-Wide association study of quantitative biomarkers identifies a novel locus for alzheimer’s disease at 12p12.1
Genetic study of quantitative biomarkers in Alzheimer’s Disease (AD) is a promising method to identify novel genetic factors and relevant endophenotypes, which provides valuable information to deconvolute mech...
Citation: BMC Genomics 2022 23:85 -
DNA methylation signature of a lifestyle-based resilience index for cognitive health
Cognitive resilience (CR) contributes to the variability in risk for developing and progressing in Alzheimer’s disease (AD) among individuals. Beyond genetics, recent studies highlight the critical role of lif...
Citation: Alzheimer's Research & Therapy 2025 17:88 -
A genome-wide search for pleiotropy in more than 100,000 harmonized longitudinal cognitive domain scores
More than 75 common variant loci account for only a portion of the heritability for Alzheimer’s disease (AD). A more complete understanding of the genetic basis of AD can be deduced by exploring associations w...
Citation: Molecular Neurodegeneration 2023 18:40 -
Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer’s disease
Simultaneous consideration of two neuropathological traits related to Alzheimer’s disease (AD) has not been attempted in a genome-wide association study.
Citation: Alzheimer's Research & Therapy 2018 10:22