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Here the authors reveal a study of 486,956 Han Chinese individuals showing that most people with genetic variants affecting drug response do not have the predicted adverse events, highlighting the challenges of implementing pharmacogenetics in clinical practice.

Researchers used artificial intelligence to mine global venom proteomes and discovered novel peptides with antimicrobial activity. Several candidates showed efficacy against drug-resistant bacteria in laboratory and animal tests.

A high-bandwidth neuromotor interface offers performant out-of-the-box generalization across people.

Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

Here, the authors show that the skin microbiome of a remote hunter-gatherer Yanomami community harbors environmental microbes that help maintain skin barrier integrity and combat oxidative stress—functions that are reduced by industrial lifestyles.

Recent theoretical studies indicate that the Kitaev model may be realized in framework materials exhibiting extended superexchange pathways. Here the authors report experimental evidence showing that the material requirements for a Kitaev quantum spin liquid are satisfied in a inorganic framework material.

The Perseverance rover has made the most definitive identification of Fe-phosphate minerals on Mars to date. High-resolution chemical and textural PIXL analyses suggest they originally formed after vivianite in a potentially habitable environment.

Superlattices, with a length scale and structure that differs from the parent lattice of the host material, are well-known to allow for remarkable new electronic and magnetic properties. Here, Xie et al. synthesize Cr_1/4TaS₂, and find that it exhibits an unusual anomalous Hall effect below the Néel temperature even in stoichiometric high-quality crystals.

Magnetic dipoles are the lowest order term in a multipolar expansion. The next allowed in centrosymmetric materials is a magnetic octupole, but this is notoriously difficult to probe experimentally, due to a lack of direct coupling to external fields. Here, Ye et al demonstrate a method to overcome this in PrV₂Al₂₀.”

The heavy fermion material URu₂Si₂ exhibits a hidden-order phase transition that remains poorly understood. Using differential elastoresistance measurements, Riggs et al. show that this phase has a nematic component and that it spontaneously breaks fourfold lattice symmetry.

Mendelian randomization (MR) identifies causal relationships from observational data but has increased error rates when the genetic variants used as instruments come from a single region, a typical scenario when assessing molecular traits like protein or metabolite levels as risk factors. Here the authors introduce a single-region pleiotropy-robust MR method, validating the method on three ground truth sources, showing its capability to identify disease-causing molecular traits.

The realization of the anomalous Hall effect in high-mobility two dimensional electron systems has so far remained elusive. Here, the authors observe its emergence in MgZnO/ZnO heterostructures and attribute it to skew scattering of electrons by localized paramagnetic centres.

Magnetically intercalated transition metal dichalcogenides provide a platform to study the interplay of magnetism, electronic band structures, and correlations. Here the authors demonstrate a nearly magnetization-free anomalous Hall effect, collinear antiferromagnetism and non-Fermi liquid behavior in V_1/3NbS₂.

The spin–orbit interaction and the two-dimensional honeycomb structure of iridium-based oxides are promising for exotic electronic states. Here, the authors find an iridium oxide with a three-dimensional structure that preserves the features of the honeycomb systems, creating new material possibilities.

Hard carbons are considered the most suitable negative electrode materials for Na-ion batteries. Here, authors use electron paramagnetic resonance spectroscopy to determine the spin nature of mechanochemically-modified hard carbons to predict their charge storage mechanism for sodium-ion batteries.

High-valent metal nitrides are difficult to stabilise due to the high thermodynamic stability and chemical inertness of N₂. Here, the authors employ a large volume press to prepare an iron(IV) nitridoferrate Ca₄Fe^IVN₄ from Fe₂N and Ca₃N₂ via azide-mediated oxidation under high pressure conditions.

Evidence for quantum criticality in Fe-based superconductors is still being accumulated. Here, the authors observe power-law behavior of the elastoresistivity as a function of composition in Ba(Fe_1−xCo_x)₂As₂ near a putative nematic quantum critical point, consistent with expectations for quantum criticality, while the temperature dependence near the critical doping deviates from a power law.

Nitrogen-rich Ruddlesden–Popper nitrides are notoriously difficult to stabilize. Now a high-pressure high-temperature synthesis method has enabled the preparation of Pr₂ReN₄, Nd₂ReN₄ and Ce₂TaN₄. Neutron diffraction analysis reveals fully nitrided materials and intricate magnetic structures.

The anomalous Hall effect is a macroscopic manifestation of a quantum mechanical effect. Here, Uelandet al. report the observation of a high Hall conductivity in the heavy-fermion compound UCu5, a metallic system, and explain its origin in terms of geometric frustration effects.

The magnetocaloric effect could allow for more efficient refrigeration compared to traditional vapour compression, however, it requires materials with large magnetocaloric coefficients, and these typically require rare-earths. Herein, Levinsky et al. demonstrate a large magnetocaloric effect in a rare-earth free layered coordination polymer.

Two-dimensional honeycomb lattices of magnetic ions with strong spin-orbit coupling can host a rich variety of magnetic phases, including Kitaev quantum spin liquids. Here, Okuma et al succeeded in synthesising powders and single crystals of β-Na2PrO3, with Praseodymium ions with very strong spin-orbit coupling arranged in a three-dimensional hyperhoneycomb lattice.

Some cancer cells exhibit high loads of reactive iron in lysosomes, and this feature is exploited by using fentomycin-1, a newly developed small molecule, to induce ferroptosis.

Ferroelectric orders hardly exist in liquid or ice state of water, despite its enormous molecular electrical polarizability. Here, Gorshunov et al. report incipient ferroelectricity in chains of interacting water molecules by placing them in the structural channels of a beryl crystal.

Detailed neutron scattering, magnetic susceptibility and muon spin relaxation studies indicate the absence of long-range magnetic order in the quantum magnet TbInO₃ down to 0.46 K— an observation consistent with quantum spin liquid behaviour.

How signaling pathways recruit SWI/SNF chromatin remodeling complexes is not known. Here the authors suggest a ubiquitin directed mechanism targeting SWI/SNF for Wnt pathway dependent transcription, important for development and cancer.

Using the Tara Oceans dataset, this study describes global patterns of diatom diversity, abundance and adaptation. The authors identify 25 distinct communities, with the Arctic as a hotspot, and highlight diatom transcriptional features. These insights aid understanding of the ecological roles of diatoms and their responses to global change.

Recent experiments reported the Kondo effect in 1H/1T dichalcogenide hetero-bilayers. Crippa et al. re-examine this interpretation using ab initio calculations and dynamical mean-field theory demonstrating strong charge transfer sensitive to the interlayer separation, indicative of a doped Mott insulator regime.

While many semiconducting materials have been extensively explored for spintronic applications, issues regarding device performance, materials stability, and efficient spin current generation at room temperature persist. Here, the authors show that a nonconjugated radical polymer is an exceptional spin transport medium.