The NIH HPC group plans, manages and supports
high-performance computing systems specifically for use by the
intramural NIH community. These systems include
Biowulf,
a 105,000+ processor
Linux cluster;
Helix, an interactive system for
file transfer and management, and
Helixweb, which provides a number of web-based
scientific tools. We provide access to a wide range of computational
applications for genomics, molecular and structural biology, mathematical and
graphical analysis, image analysis, and other scientific fields.
The continued growth and support of NIH's Biowulf cluster is dependent upon
its demonstrable value to the NIH Intramural Research Program. If you publish
research that involved significant use of Biowulf, please cite the cluster.
Suggested citation text:
This work utilized the computational resources of the NIH HPC Biowulf cluster (https://hpc.nih.gov).
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Quick Links
Biowulf Utilization
Thursday, July 24th, 2025
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Last 24 hrs
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92,786 jobs submitted
69,991 jobs completed
3,157,290 CPU hrs used
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23 NIH Institutes
317 Principal Investigators
673 users
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Announcements
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Recent Papers that used Biowulf & HPC Resources
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Basal ganglia activation localized in MEG using a reward task
Sepe-Forrest, L; Carver, FW; Quentin, R et al.
Neuroimage Rep
, DOI://10.1016/j.ynirp.2021.100034 (2021)
A Dataset of Medical Questions Paired with Automatically Generated Answers and Evidence-supported References
Gupta, D; Bartels, D; Demner-Fushman, D; ,
Sci Data
, DOI://10.1038/s41597-025-05233-z (2025)
EzSEA: an interactive web interface for enzyme sequence evolution analysis
Jiang, AK; Zhao, J; Jiang, X; ,
Bioinform Adv
, DOI://10.1093/bioadv/vbaf118 (2025)
Material properties of biomolecular condensates emerge from nanoscale dynamics
Galvanetto, N; Ivanović, MT; Del Grosso, SA et al.
Proc Natl Acad Sci U S A
, DOI://10.1073/pnas.2424135122 (2025)
Tevenvirinae phages encode a family of LSm-like fold proteins
Kim, J; Tai, CH; Livingston, NK et al.
Comput Struct Biotechnol J
, DOI://10.1016/j.csbj.2025.05.028 (2025)
GBA1 rs3115534 Is Associated with REM Sleep Behavior Disorder in Parkinson's Disease in Nigerians
Ojo, OO; Bandres-Ciga, S; Makarious, MB et al.
Mov Disord
, DOI://10.1002/mds.29753 (2024)
Optimization of the PROTAC linker region of the proteasome substrate receptor hRpn13 rationalized by structural modeling with molecular dynamics
Lu, X; Sabbasani, VR; Hassan, B et al.
J Biol Chem
, DOI://10.1016/j.jbc.2025.108520 (2025)
SECONDGRAM: Self-conditioned diffusion with gradient manipulation for longitudinal MRI imputation
Theodorou, B; Dadu, A; Nalls, M et al.
Patterns (N Y)
, DOI://10.1016/j.patter.2025.101212 (2025)
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