According to the Qt 5 doc, there is way to build a universal Qt app for both intel/apple silicon
https://doc.qt.io/archives/qt-5.15/macos.html#architectures

Qt added the universal app support in Qt 5.15.9 and it's now open sourced. So it's possible to create a Pencil2D universal mac app.

A universal binary provides optimal performance on both processor types and simplify distribution with only one single app package.