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What is a hidden Markov model?

Statistical models called hidden Markov models are a recurring theme in computational biology. What are hidden Markov models, and why are they so useful for so many different problems?

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Figure 1: A toy HMM for 5′ splice site recognition.

References

  1. Rabiner, L.R. A tutorial on hidden Markov models and selected applications in speech recognition. Proc. IEEE 77, 257–286 (1989).

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  2. Durbin, R., Eddy, S.R., Krogh, A. & Mitchison, G.J. Biological Sequence Analysis: Probabilistic Models of Proteins and Nucleic Acids (Cambridge University Press, Cambridge UK, 1998).

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Eddy, S. What is a hidden Markov model?. Nat Biotechnol 22, 1315–1316 (2004). https://doi.org/10.1038/nbt1004-1315

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  • DOI: https://doi.org/10.1038/nbt1004-1315

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