这是indexloc提供的服务,不要输入任何密码
Skip to main content
Log in

Multiple testing correction for mean tests in time series rolling window analysis with an application of GWAS methods

  • Original Paper
  • Published:
Statistical Methods & Applications Aims and scope Submit manuscript

Abstract

Rolling window analysis is a popular tool in time series research. However, conducting hypothesis tests on all rolling windows simultaneously introduces a multiple testing problem. In the literature, bootstrapping the maximum of all statistics from rolling windows is the most commonly used, if not the only, method to address this issue. This paper seeks to provide a simpler and faster alternative to bootstrap methods by adapting p-value combination techniques that are popular in genome-wide association studies to the context of mean tests in a time series rolling window analysis. Some p-value combination methods in genetics require knowledge of the correlation structure of test statistics, which can typically be obtained from external sources. However, such information is often unavailable for time series datasets. To address this challenge, we employ the autoregressive sieve approach, which allows for the computation of correlation structures based on estimated autoregressive coefficients. We present finite sample simulations to illustrate the performance of p-value combination methods in a rolling window setting and offer recommendations for practitioners and future researchers in this area.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8

Similar content being viewed by others

Explore related subjects

Discover the latest articles and news from researchers in related subjects, suggested using machine learning.

References

  • Alonso AM, Peña D, Romo J (2003) On sieve bootstrap prediction intervals. Stat & Probab Lett 65(1):13–20

    Article  MathSciNet  Google Scholar 

  • Andrews DW (1991) Heteroskedasticity and autocorrelation consistent covariance matrix estimation. Econ: J Econ Soc. https://doi.org/10.2307/2938229

    Article  Google Scholar 

  • Andre’es MA, Pena D, Romo J (2002) Forecasting time series with sieve bootstrap. J Stat Plan Inference 100(1):1–11

    Article  MathSciNet  Google Scholar 

  • Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Roy Stat Soc: Ser B (Methodol) 57(1):289–300

    Article  MathSciNet  Google Scholar 

  • Bland JM, Altman DG (1995) Multiple significance tests: the Bonferroni method. BMJ 310(6973):170

    Article  Google Scholar 

  • Bonferroni C (1936) Teoria statistica delle classi e calcolo delle probabilita. Pubblicazioni del R Istituto Superiore di Scienze Economiche e Commericiali di Firenze 8:3–62

    Google Scholar 

  • Bühlmann P (1997) Sieve bootstrap for time series. Bernoulli 123–148

  • Bühlmann P (1998) Sieve bootstrap for smoothing in nonstationary time series. Ann Stat 26(1):48–83

    Article  MathSciNet  Google Scholar 

  • Bühlmann P (2002) Bootstraps for time series. Stat Sci 71(2):435–459

    MathSciNet  Google Scholar 

  • Conneely KN, Boehnke M (2007) So many correlated tests, so little time! Rapid adjustment of P values for multiple correlated tests. Am J Hum Genet 81(6):1158–1168

    Article  Google Scholar 

  • Cryer JD, Chan K-S (2008) Time series analysis: With applications in R, vol 2. Springer

    Book  Google Scholar 

  • Good IJ (1958) Significance tests in parallel and in series. J Am Stat Assoc 53(284):799–813

    Article  MathSciNet  Google Scholar 

  • Härdle W, Horowitz J, Kreiss J-P (2003) Bootstrap methods for time series. Int Stat Rev 71(2):435–459

    Article  MathSciNet  Google Scholar 

  • Huang P, Tilley BC, Woolson RF, Lipsitz S (2005) Adjusting O’brien’s test to control type I error for the generalized nonparametric behrens-fisher problem. Biometrics 61(2):532–539

    Article  MathSciNet  Google Scholar 

  • Hušková M, Kirch C, Prášková Z, Steinebach J (2008) On the detection of changes in autoregressive time series, II. Resampling procedures. J Stat Plan Inference 138(6):1697–1721

    Article  MathSciNet  Google Scholar 

  • Hušková M, Prášková Z, Steinebach J (2007) On the detection of changes in autoregressive time series I. Asymptotics. J Stat Plan Inference 137(4):1243–1259

    Article  MathSciNet  Google Scholar 

  • Kim J, Bai Y, Pan W (2015) An adaptive association test for multiple phenotypes with gwas summary statistics. Genet Epidemiol 39(8):651–663

    Article  Google Scholar 

  • Kreiss J-P, Paparoditis E, Politis DN (2011) On the range of validity of the autoregressive sieve bootstrap. Ann Stat 39(4):2103–2130

    Article  MathSciNet  Google Scholar 

  • Li M-X, Gui H-S, Kwan JS, Sham PC (2011) Gates: a rapid and powerful gene-based association test using extended simes procedure. Am J Hum Genet 88(3):283–293

    Article  Google Scholar 

  • McCaw ZR, Colthurst T, Yun T, Furlotte NA, Carroll A, Alipanahi B, McLean CY, Hormozdiari F (2022) Deepnull models non-linear covariate effects to improve phenotypic prediction and association power. Nat Commun 13(1):1–10

    Article  Google Scholar 

  • Moran MD (2003) Arguments for rejecting the sequential Bonferroni in ecological studies. Oikos 100(2):403–405

    Article  Google Scholar 

  • Müller UK (2014) HAC corrections for strongly autocorrelated time series. J Bus & Econ Stat 32(3):311–322

    Article  MathSciNet  Google Scholar 

  • Newey WK, West KD (1987) A simple, positive semi-definite, heteroskedasticity and autocorrelation. Econometrica 55(3):703–708

    Article  MathSciNet  Google Scholar 

  • Ray D, Boehnke M (2018) Methods for meta-analysis of multiple traits using gwas summary statistics. Genet Epidemiol 42(2):134–145

    Article  Google Scholar 

  • Shi S, Hurn S, Phillips PC (2020) Causal change detection in possibly integrated systems: revisiting the money-income relationship. J Financ Economet 18(1):158–180

    Article  Google Scholar 

  • Shi S, Phillips PC, Hurn S (2018) Change detection and the causal impact of the yield curve. J Time Ser Anal 39(6):966–987

    Article  MathSciNet  Google Scholar 

  • Simes RJ (1986) An improved Bonferroni procedure for multiple tests of significance. Biometrika 73:751–754

    Article  MathSciNet  Google Scholar 

  • Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, Pirruccello JP, Ripatti S, Chasman DI, Willer CJ et al (2010) Biological, clinical and population relevance of 95 loci for blood lipids. Nature 466(7307):707–713

    Article  Google Scholar 

  • Uchaikin VV, Zolotarev VM (2011) Chance and stability: stable distributions and their applications. Walter de Gruyter

  • Van der Sluis S, Posthuma D, Dolan CV (2013) Tates: Efficient multivariate genotype-phenotype analysis for genome-wide association studies. PLoS Genet 9(1):e1003235

    Article  Google Scholar 

  • Westman V (2021) A small sample study of some sandwich estimators to handle heteroscedasticity

  • Wilson DJ (2019) The harmonic mean \(p\)-value for combining dependent tests. Proc Natl Acad Sci 116(4):1195–1200

    Article  MathSciNet  Google Scholar 

  • Yang Q, Wu H, Guo C-Y, Fox CS (2010) Analyze multivariate phenotypes in genetic association studies by combining univariate association tests. Genet Epidemiol 34(5):444–454

    Article  Google Scholar 

  • Zeileis A (2004) Econometric computing with HC and HAC covariance matrix estimators. J Stat Softw 11(i10):1–17

    Google Scholar 

Download references

Acknowledgements

Rho was supported by NSF-CPS-1739422 and NIH-R15GM135806.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Yeonwoo Rho.

Ethics declarations

Conflict of interest

The authors declare no Conflict of interest and no Conflict of interest. No datasets were generated or analyzed in this study beyond those created for the simulation. The authors would like to thank the two anonymous referees and the Editor for their constructive comments that significantly improved the quality of this paper.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary Information

Below is the link to the electronic supplementary material.

Supplementary file 1 (pdf 2106 KB)

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wang, S., Rho, Y. Multiple testing correction for mean tests in time series rolling window analysis with an application of GWAS methods. Stat Methods Appl (2025). https://doi.org/10.1007/s10260-025-00789-x

Download citation

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s10260-025-00789-x

Keywords

Mathematics Subject Classification